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Simparica TRIO Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses

Simparica TRIO

Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses

Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses is a chewable tablet for large dogs that prevents fleas, ticks, and heartworms. Priced at $230.88, it offers year-round protection with monthly dosing for dogs weighing 44.1 to 88 lbs.

$230.88

● In stock

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Key features

  • Triple parasite protection in one chew
  • Kills fleas within 4 hours
  • Effective against multiple tick species
  • Prevents heartworm, roundworm, hookworm
  • Monthly chewable tablet for 12 months
  • For dogs 44.1-88 lbs, green pack
  • No food requirement for administration

Pros

  • +Fast flea and tick elimination
  • +Broad-spectrum internal and external protection
  • +Easy-to-give chewable tablet
  • +Trusted brand with proven efficacy
  • +Year-round coverage with 12 doses
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Cons

  • Requires prescription
  • Higher cost than single-target preventives
  • Not for dogs under 44.1 lbs
  • Possible side effects like vomiting or diarrhea

About Simparica TRIO Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses

What is Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses?

Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses is a veterinarian-recommended, once-monthly chewable tablet designed for large dogs. It provides broad-spectrum protection against fleas, ticks, heartworm disease, roundworms, and hookworms. Each pack contains 12 monthly doses, ensuring full-year coverage. Manufactured by Zoetis, Simparica Trio combines three active ingredients—sarolaner, moxidectin, and pyrantel—to deliver comprehensive internal and external parasite control. This product is ideal for pet owners seeking reliable, easy-to-administer prevention for dogs weighing between 44.1 and 88 pounds.

Key features

  • Triple Protection — targets fleas, ticks, heartworms, roundworms, and hookworms in one monthly dose.
  • Chewable Tablet — palatable formula designed for easy administration without food requirements.
  • Year-Round Coverage — 12-dose pack supports uninterrupted monthly protection.
  • Fast-Acting — kills fleas within 4 hours and ticks within 8 hours of administration.
  • For Large Dogs — formulated specifically for dogs weighing 44.1 to 88 lbs (green color-coded packaging).
  • Prescription-Based — requires veterinary approval to ensure safe and appropriate use.
  • Trusted Brand — developed by Zoetis, a leading animal health company.

Who is Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses for?

This product is intended for dog owners with large breeds weighing 44.1 to 88 pounds who are looking for a convenient, effective way to protect their pets from common parasites. It's especially beneficial for dogs that spend time outdoors, where exposure to fleas and ticks is higher. It’s suitable for dogs 8 weeks of age and older, but a vet consultation is required before use to confirm health suitability.

How does Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses compare?

Compared to single-action flea or tick preventives, Simparica Trio offers broader protection by also preventing heartworm, roundworm, and hookworm infections. It outperforms standard polypropylene-based collars and topical treatments by delivering faster flea and tick kill times. Unlike some monthly chews that require food for absorption, Simparica Trio can be given with or without meals. While more expensive than basic flea-only chews, its comprehensive coverage justifies the cost for pet owners prioritizing full-spectrum parasite defense.

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Best use cases

  • Year-round flea and tick prevention
  • Heartworm protection in high-risk areas
  • Dogs with outdoor exposure to parasites
  • Monthly deworming for roundworms and hookworms
  • Large breed parasite management
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Is Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses right for you?

Simparica Trio is best for owners of large dogs (44.1-88 lbs) seeking comprehensive parasite protection. A vet consultation is required before purchase. It's ideal for pet parents who prefer monthly chews over topicals or collars. Alternatives include standalone heartworm preventives or flea/tick-only treatments, but they lack the combined coverage.

How it compares: Simparica Trio offers broader protection than flea-only chews or tick collars, combining internal and external parasite control. It acts faster than many topicals and provides more comprehensive coverage than single-target oral preventives, making it a premium choice for full-spectrum defense.

Are There Active Pet Express Trading Company Coupons for This Product?

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12% Off ⚠️ Unverified
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Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks, heartworms, roundworms, and hookworms. It combines three active ingredients to deliver broad-spectrum parasite prevention in a single monthly chewable tablet for dogs 44.1-88 lbs.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a prescription from a licensed veterinarian. This ensures the medication is safe for your dog’s health condition and weight, and confirms they’ve been tested for heartworm before starting treatment.

How quickly does Simparica Trio kill fleas and ticks?

Simparica Trio kills fleas within 4 hours and begins killing ticks within 8 hours of administration. It provides continuous protection throughout the month, helping prevent infestations and disease transmission.

Is Simparica Trio safe for all dogs?

Simparica Trio is safe for dogs 8 weeks of age and older weighing 44.1 to 88 lbs. It should not be used in dogs with a history of seizures or neurological disorders. Always consult your vet before starting treatment.

Can I give Simparica Trio with food?

Yes, Simparica Trio can be given with or without food. The chewable tablet is designed to be palatable, making administration easier. If your dog experiences stomach upset, giving it with a meal may help.

How much does Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses cost?

Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses is $230.88 at Pet Express Trading Company. Prices may change — click through to Pet Express Trading Company for the latest.

Is Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses in stock at Pet Express Trading Company?

Yes, Simparica Trio For Dogs 44.1-88 Lbs (Green) 12 Doses is currently in stock at Pet Express Trading Company.

Are there coupon codes for Pet Express Trading Company?

Yes — Love Those Deals currently tracks 4 active Pet Express Trading Company coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3915
MPN
Simparica-TRIO-2148
Last updated Apr 28, 2026