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Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses

Simparica TRIO

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is a vet-recommended chewable tablet that protects dogs against fleas, ticks, and mites. Priced at $90.18, it's ideal for medium-sized dogs needing monthly broad-spectrum parasite control.

$90.18

● In stock

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Key features

  • Broad-spectrum protection from fleas, ticks, heartworms, and mites
  • Starts killing fleas in 4 hours, ticks in 8 hours
  • Palatable chewable tablet for easy administration
  • 6-month supply with one box of 6 doses
  • For dogs 22.1–44 lbs, 8 weeks and older
  • FDA-approved oral parasiticide
  • Once-monthly dosing simplifies routine

Pros

  • +Fast flea and tick kill times
  • +Protects against multiple parasites
  • +No mess, unlike topical treatments
  • +Convenient monthly dosing
  • +High palatability for dogs
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Cons

  • Requires prescription from vet
  • Not suitable for dogs under 22.1 lbs
  • Potential for side effects like vomiting

About Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses

What is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is a monthly chewable tablet designed for medium-sized dogs weighing between 22.1 and 44 pounds. Manufactured by Zoetis, this FDA-approved medication provides comprehensive protection against fleas, ticks, mange mites, and heartworm disease. Each pack contains six monthly doses, offering a full half-year of parasite prevention. The blue chewable tablets are flavored to improve palatability, making administration easier for pet owners.

Key features

  • Broad-Spectrum Protection — Targets fleas, ticks, heartworms, and mites in one monthly dose.
  • Fast-Acting Formula — Starts killing fleas within 4 hours and ticks within 8 hours.
  • Convenient Chewable Form — Palatable tablet that most dogs accept easily.
  • 6-Month Supply — Includes six pre-dosed tablets for continuous protection.
  • For Medium-Sized Dogs — Specifically formulated for dogs weighing 22.1–44 lbs.
  • FDA-Approved — Backed by veterinary science and clinical testing.
  • Once-Monthly Dosing — Simplifies parasite prevention with consistent scheduling.

Who is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses for?

This product is ideal for dog owners seeking reliable, long-term protection for medium-sized breeds. It’s especially beneficial for pets in regions with high tick and flea activity or those frequently exposed to outdoor environments. Veterinarians often recommend Simparica Trio for dogs needing integrated parasite control without topical applications. It’s suitable for dogs 8 weeks of age and older.

How does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses compare?

Compared to single-target flea or tick preventives, Simparica Trio offers broader coverage by also preventing heartworm and mange mites. Unlike topical treatments, it leaves no residue and isn’t affected by swimming or bathing. While some oral alternatives require fasting, Simparica Trio can be given with or without food. It acts faster than many monthly chews and is more convenient than multi-product regimens typically needed for full parasite defense.

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Best use cases

  • Monthly flea and tick prevention
  • Heartworm disease prevention
  • Mange mite infestation control
  • Year-round parasite protection
  • Dogs in tick-prone regions
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Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses right for you?

Simparica Trio is best for owners of medium-sized dogs (22.1–44 lbs) seeking comprehensive, once-monthly parasite protection. A veterinary prescription is required. It's ideal for pet parents who prefer oral chews over topical solutions. Alternatives include other oral preventives like NexGard or topical treatments such as Frontline.

How it compares: Simparica Trio outperforms single-target oral chews and topical treatments by combining flea, tick, heartworm, and mite control in one fast-acting tablet, reducing the need for multiple medications.

Are There Active Pet Express Trading Company Coupons for This Product?

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12% Off ⚠️ Unverified
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Best Deal for Labor Day Sale Plus Extra 12% Off & Free Shipping on All Orders in Us! Use Coupon: CPC12ON

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Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks, heartworms, and mites like those that cause mange. It's a broad-spectrum preventive that covers multiple parasites in one monthly dose, making it a comprehensive choice for year-round protection.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a prescription from a licensed veterinarian. It is a prescription-only medication due to its active pharmaceutical ingredients and the need for proper dosing based on your dog’s weight and health status.

How quickly does Simparica Trio work?

Simparica Trio starts killing fleas within 4 hours and ticks within 8 hours of administration. Its fast action helps prevent infestations and reduces the risk of disease transmission from biting parasites.

Is Simparica Trio safe for all dogs?

Simparica Trio is safe for dogs 8 weeks of age and older weighing 22.1–44 lbs. It is not recommended for dogs with a history of seizures. Always consult your vet before starting any new medication.

Can I give Simparica Trio with food?

Yes, Simparica Trio can be given with or without food. The chewable tablet is designed to be palatable, and taking it with a meal may help reduce the chance of stomach upset in sensitive dogs.

How much does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses cost?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is $90.18 at Pet Express Trading Company. Prices may change — click through to Pet Express Trading Company for the latest.

Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses in stock at Pet Express Trading Company?

Yes, Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is currently in stock at Pet Express Trading Company.

Are there coupon codes for Pet Express Trading Company?

Yes — Love Those Deals currently tracks 4 active Pet Express Trading Company coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3915
GTIN
87219131589
MPN
Simparica-TRIO-2144
Last updated Apr 28, 2026