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Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses

Simparica TRIO

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is a vet-recommended chewable tablet that protects dogs against fleas, ticks, mites, and heartworms. Priced at $176.28, it's ideal for medium-sized dogs needing year-round parasite defense with minimal effort from owners.

$176.28

● In stock

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Key features

  • Triple parasite protection: fleas, ticks, heartworms
  • Fast-acting: kills fleas in 4 hours, ticks in 8
  • Monthly chewable tablet with beef flavor
  • 12-dose supply for full-year coverage
  • Waterproof – no reapplication after swimming
  • Vet-approved and FDA-registered
  • For dogs 22.1–44 lbs, 8 weeks and older

Pros

  • +Convenient once-a-month dosing
  • +Highly effective against multiple parasites
  • +No mess compared to topical treatments
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Cons

  • Requires prescription from a vet
  • Not suitable for dogs under 22.1 lbs

About Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses

What is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is a monthly chewable tablet designed for medium-sized dogs weighing between 22.1 and 44 pounds. Manufactured by Zoetis, this FDA-approved medication provides broad-spectrum protection against multiple parasites, including fleas, ticks (including deer ticks that carry Lyme disease), mange mites, and heartworms. Each pack contains 12 monthly doses, offering a full year of continuous protection. The blue chewable tablets are flavored to improve palatability, making administration easier for pet owners.

Key features

  • Triple Protection — Targets fleas, ticks, and internal parasites including heartworm, hookworm, and roundworm.
  • Monthly Chewable — Easy-to-administer tablet taken once per month with food.
  • Fast-Acting — Starts killing fleas within 4 hours and ticks within 8 hours.
  • Year-Round Coverage — 12-dose supply ensures uninterrupted protection.
  • Vet-Recommended — Trusted brand prescribed by veterinarians nationwide.
  • Waterproof — No need to reapply after swimming or bathing.
  • Size-Specific Dosing — Formulated for dogs 22.1–44 lbs to ensure safety and efficacy.

Who is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses for?

This product is designed for dog owners seeking a reliable, once-a-month solution to protect their medium-sized dogs from common parasites. It’s especially beneficial for pets that spend time outdoors, live in tick-prone areas, or require heartworm prevention. Not suitable for dogs under 8 weeks of age or weighing less than 22.1 lbs. Always consult a veterinarian before starting any new medication.

How does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses compare?

Compared to single-purpose flea treatments or topical solutions, Simparica Trio offers broader protection in a convenient oral format. Unlike standard polypropylene rugs or fixed overhead cranes, which serve entirely different functions, this product competes with other oral parasiticides like NexGard or Heartgard Plus—but combines three critical protections in one dose. It eliminates the need for multiple products, reducing complexity in pet care routines while maintaining high efficacy.

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Best use cases

  • Year-round flea and tick prevention
  • Heartworm protection in high-risk areas
  • Dogs that swim or bathe frequently
  • Owners preferring oral over topical treatments
  • Medium-sized dogs in rural or wooded areas
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Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses right for you?

Simparica Trio is best for owners of medium-sized dogs (22.1–44 lbs) seeking comprehensive, low-maintenance parasite protection. A veterinary prescription is required. Ideal for those who prefer oral chews over messy topicals. Alternatives include NexGard (flea/tick only) or Heartgard Plus (heartworm + intestinal worms), but Simparica Trio combines both benefits.

How it compares: Simparica Trio outperforms single-target flea chews and topical treatments by combining heartworm, flea, tick, and mite protection in one monthly dose, reducing the need for multiple products and simplifying pet care routines.

Are There Active Pet Express Trading Company Coupons for This Product?

15% Off ⚠️ Unverified
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12% Off ⚠️ Unverified
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Enjoy 12% Discount on All Pet Supplies Products for Labor Day Sale Plus Free Shipping! Use Coupon: CPC12ON

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12% Off ⚠️ Unverified
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Best Deal for Labor Day Sale Plus Extra 12% Off & Free Shipping on All Orders in Us! Use Coupon: CPC12ON

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15% Off ⚠️ Unverified
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Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks (including deer ticks), mange mites, heartworm, hookworm, and roundworm. It offers broad-spectrum parasite control in a single monthly chewable tablet, making it a comprehensive solution for year-round pet health.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a prescription from a licensed veterinarian. It is a prescription-only medication due to its active pharmaceutical ingredients and the need for proper dosing based on your dog’s weight and health status.

How quickly does Simparica Trio work?

Simparica Trio starts killing fleas within 4 hours and ticks within 8 hours of administration. Its fast action helps prevent infestations and reduces the risk of disease transmission from biting parasites like ticks.

Is Simparica Trio safe for all dogs?

Simparica Trio is safe for dogs 8 weeks of age and older weighing 22.1–44 lbs. It has not been evaluated for use in breeding, pregnant, or lactating dogs. Consult your vet before use if your dog has a history of seizures.

Can I give Simparica Trio with food?

Yes, Simparica Trio should be given with food to ensure proper absorption. The beef-flavored chew is designed to be palatable and can be mixed with a regular meal to make administration easier for most dogs.

How much does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses cost?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is $176.28 at Pet Express Trading Company. Prices may change — click through to Pet Express Trading Company for the latest.

Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses in stock at Pet Express Trading Company?

Yes, Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is currently in stock at Pet Express Trading Company.

Are there coupon codes for Pet Express Trading Company?

Yes — Love Those Deals currently tracks 4 active Pet Express Trading Company coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3915
MPN
Simparica-TRIO-2145
Last updated Apr 28, 2026