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Simparica TRIO Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses

Simparica TRIO

Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses

Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses is a vet-recommended chewable tablet that protects large dogs from fleas, ticks, and mites. Priced at $273.13, it's ideal for pet owners seeking long-term, monthly parasite control with proven efficacy and ease of use.

$273.13

● In stock

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Price and availability may change. Click to see current details on BestVetCare.

Key features

  • Triple protection against fleas, ticks, and heartworm
  • Fast-acting: kills fleas in 4 hours, ticks in 8
  • 12-month supply for uninterrupted defense
  • Meat-flavored chewable for easy administration
  • FDA-approved, vet-recommended formula
  • Specifically for dogs over 88 lbs
  • Prevents mites that cause skin and ear issues

Pros

  • +Highly effective against multiple parasites
  • +Easy to give with palatable chewable form
  • +Backed by veterinary research and approval
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Cons

  • Requires prescription, not OTC
  • Higher upfront cost than some alternatives

About Simparica TRIO Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses

What is Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses?

Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses is a prescription-strength, chewable tablet designed for large breed dogs weighing over 88 pounds. Formulated to deliver comprehensive protection, it targets fleas, ticks, and mites—including those that may cause Lyme disease—while also preventing heartworm disease. Each pack contains 12 monthly doses, ensuring a full year of consistent, reliable parasite defense. Manufactured by Zoetis, Simparica Trio is FDA-approved and widely recommended by veterinarians for dogs in high-risk environments or active outdoor lifestyles.

Key features

  • Triple Protection — Targets fleas, ticks, and mites while preventing heartworm disease.
  • Monthly Chewable — Easy-to-administer tablet with a meaty flavor dogs accept readily.
  • Fast-Acting Formula — Starts killing fleas within 4 hours and ticks within 8 hours.
  • Year-Round Supply — 12-dose pack ensures uninterrupted protection for one full year.
  • For Large Dogs — Specifically dosed for dogs over 88 lbs, maximizing safety and efficacy.
  • Prescription-Based — Requires vet approval, ensuring proper use and health monitoring.
  • Proven Efficacy — Backed by clinical trials and trusted by veterinary professionals.

Who is Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses for?

This product is ideal for owners of large breed dogs—such as Great Danes, Saint Bernards, or Mastiffs—who need reliable, year-round parasite protection. It’s especially beneficial for dogs that spend time outdoors, travel frequently, or live in regions with high tick and flea prevalence. Because it requires a prescription, it’s best suited for pet owners with access to veterinary care and those prioritizing FDA-approved treatments over over-the-counter options.

How does Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses compare?

Compared to standard flea and tick chews, Simparica Trio offers broader protection by also preventing heartworm and killing multiple tick species. It acts faster than many monthly topicals and eliminates the mess associated with liquid applications. While some generic alternatives may cost less, they often lack the same clinical backing or triple-action formula. Compared to fixed-dose combination treatments, Simparica Trio’s weight-specific dosing enhances safety for large dogs, reducing the risk of under- or overdosing.

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Best use cases

  • Year-round flea and tick prevention
  • Heartworm protection in endemic areas
  • Outdoor or hunting dog parasite control
  • Large breed dogs over 88 lbs
  • Veterinary-recommended parasite management
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Is Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses right for you?

Simparica Trio is best for owners of large dogs seeking reliable, vet-approved parasite protection. A prescription is required, so consult your veterinarian first. Ideal for those prioritizing efficacy over cost. Alternatives include generic heartworm preventives or topical treatments, but they may not offer the same broad-spectrum coverage.

How it compares: Simparica Trio outperforms standard polypropylene rugs in durability and offers better UV resistance than basic outdoor fabrics, making it ideal for long-term outdoor use in harsh conditions.

Are There Active BestVetCare Coupons for This Product?

20% Off ⚠️ Unverified
Expires May 31
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Summer Must-Haves for Pets – 20% OFF Heartworm Prevention + Free Shipping*

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20% Off ⚠️ Unverified
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Summer Must-Haves for Pets – 20% OFF Heartworm Prevention + Free Shipping*

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10% Off ⚠️ Unverified
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Set Auto-order & Get Extra 10% Discount

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30% Off ⚠️ Unverified
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Hop into Spring Deals - 30% OFF Flea & Tick Treatments + Free Shipping!

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Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks (including black-legged, American dog, and lone star ticks), mites, and prevents heartworm disease. It’s a comprehensive monthly chewable designed for large dogs over 88 lbs, offering broad-spectrum parasite control.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a prescription from a licensed veterinarian. This ensures the medication is appropriate for your dog’s health status and weight, and allows for proper monitoring of any potential side effects during treatment.

How quickly does Simparica Trio work?

Simparica Trio starts killing fleas within 4 hours of administration and eliminates 100% of fleas within 12 hours. It begins killing ticks within 8 hours and continues to provide protection throughout the month.

Is Simparica Trio safe for all large dogs?

Simparica Trio is approved for dogs over 88 lbs and is generally safe when used as directed. However, it should not be used in dogs with a history of seizures. Always consult your vet before starting any new medication.

Can I buy Simparica Trio without a vet visit?

No, Simparica Trio requires a valid prescription, which means a veterinarian must first examine your dog and approve the treatment. Online purchases still require prescription verification before shipment.

How much does Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses cost?

Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses is $273.13 at BestVetCare. Prices may change — click through to BestVetCare for the latest.

Is Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses in stock at BestVetCare?

Yes, Simparica Trio For Dogs Above 88 Lbs (Brown) 12 Doses is currently in stock at BestVetCare.

Are there coupon codes for BestVetCare?

Yes — Love Those Deals currently tracks 4 active BestVetCare coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3913
MPN
Zoetis-Simparica-TRIO-2078
Last updated Apr 28, 2026