Skip to content
Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses

Simparica TRIO

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is a vet-recommended chewable tablet that protects dogs against fleas, ticks, and mites. Priced at $85.03, it's ideal for medium-sized dogs needing year-round parasite defense with minimal effort from pet owners.

$85.03

● In stock

Buy at BestVetCare →

Price and availability may change. Click to see current details on BestVetCare.

Key features

  • Triple-Action Protection — fights fleas, ticks, mites, and internal parasites
  • Monthly chewable tablet — easy to administer, no topical mess
  • Fast-acting — kills fleas in 4 hours, ticks in 8 hours
  • 30-day protection per dose — consistent, reliable coverage
  • Vet-approved formula — clinically tested and recommended
  • 6-dose pack — half-year supply with refill convenience
  • Free shipping and rewards — available at BestVetCare

Pros

  • +Broad-spectrum parasite protection
  • +Fast flea and tick kill times
  • +Easy-to-give chewable tablet
  • +Includes heartworm prevention
  • +Free shipping and loyalty rewards
!

Cons

  • Only for dogs 22.1-44 lbs
  • Not for puppies under 8 weeks
  • Requires vet consultation first

About Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses

What is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is a monthly chewable tablet designed for medium-sized dogs weighing between 22.1 and 44 pounds. Manufactured by Zoetis, this FDA-approved medication provides broad-spectrum protection against fleas, ticks, mange mites, and heartworm disease. Each pack contains six pre-measured doses, offering half a year of continuous defense in an easy-to-administer format. Sold by BestVetCare, it's available for $85.03 with free shipping and reward points on qualifying orders.

Key features

  • Triple-Action Protection — Targets fleas, ticks, and mites while preventing heartworm, hookworm, and roundworm infections.
  • Monthly Chewable Tablet — Palatable formula makes dosing simple; no topical application required.
  • Fast-Acting Relief — Starts killing fleas within 4 hours and ticks within 8 hours of administration.
  • Long-Lasting Defense — Provides full protection for 30 days per dose, ensuring consistent coverage.
  • Vet-Recommended Brand — Backed by clinical studies and trusted by veterinarians nationwide.
  • Convenient Packaging — Six-dose supply reduces refill frequency and supports auto-order discounts.
  • Free Shipping & Rewards — Available at BestVetCare with free delivery and loyalty points on purchase.

Who is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses for?

This product is designed for dog owners seeking reliable, once-a-month parasite control for medium-sized breeds. It’s especially beneficial for pets in high tick-risk areas or households wanting to avoid messy topical treatments. Not suitable for dogs under 8 weeks of age or weighing less than 22.1 lbs. Always consult a veterinarian before starting any new medication.

How does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses compare?

Compared to standard flea and tick chews, Simparica Trio offers broader coverage by also preventing heartworm, hookworm, and roundworm—features not found in single-purpose treatments. It acts faster than many oral alternatives and eliminates the mess of spot-on solutions. While more expensive than basic flea pills, its comprehensive protection justifies the cost for pet owners prioritizing full-spectrum health. It competes directly with other combination preventives but stands out for rapid kill speed and palatability.

🎯

Best use cases

  • Year-round flea and tick control
  • Heartworm prevention in at-risk areas
  • Owners avoiding topical treatments
  • Medium-sized dogs in tick-prone regions
  • Convenient monthly dosing routine
🛒

Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses right for you?

Simparica Trio is best for owners of medium-sized dogs (22.1–44 lbs) seeking comprehensive parasite protection. No special skills needed—just monthly dosing. Ideal for those avoiding messy topicals. Alternatives include other oral preventives or single-target treatments, but this offers broader coverage. Always consult your vet before switching medications.

How it compares: Simparica Trio outperforms basic flea chews and spot-ons by combining heartworm, hookworm, and roundworm prevention with rapid flea and tick kill. It's more comprehensive than single-purpose products and more convenient than messy topicals, though slightly higher priced than minimal-coverage options.

Are There Active BestVetCare Coupons for This Product?

10% Off ⚠️ Unverified
Expires Jun 4
BestVetCare

Set Auto-order & Get Extra 10% Discount

••••••••

We earn a commission if you shop through this link.

30% Off ⚠️ Unverified
Expires Jun 4
BestVetCare

Hop into Spring Deals - 30% OFF Flea & Tick Treatments + Free Shipping!

••••••••

We earn a commission if you shop through this link.

20% Off ⚠️ Unverified
Expires Jun 4
BestVetCare

Summer Must-haves for Pets €“ 20% OFF Heartworm Prevention + Free Shipping*

••••••••

We earn a commission if you shop through this link.

20% Off ⚠️ Unverified
Expires May 31
BestVetCare

Summer Must-Haves for Pets – 20% OFF Heartworm Prevention + Free Shipping*

••••••••

We earn a commission if you shop through this link.

More from BestVetCare

?

Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks, mange mites, heartworm, hookworm, and roundworm. It's a full-spectrum preventive that eliminates multiple parasites with one monthly chewable tablet, making it ideal for comprehensive pet health management.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a veterinarian's prescription. It's a prescription-only medication due to its active ingredients and health implications. Always consult your vet before starting treatment, especially for dogs with seizure history or allergies.

How quickly does Simparica Trio work?

Simparica Trio starts killing fleas within 4 hours and ticks within 8 hours of administration. It provides continuous protection for 30 days, making it one of the fastest-acting oral parasite preventives on the market.

Is Simparica Trio safe for all dogs?

Simparica Trio is safe for dogs 8 weeks and older weighing 22.1–44 lbs. It's not recommended for dogs with a history of seizures. Always consult your veterinarian to confirm suitability based on your pet’s health history.

Can I get Simparica Trio without a vet visit?

No, you cannot legally purchase Simparica Trio without a valid prescription. Most online pharmacies, including BestVetCare, require prescription verification before shipping. A vet visit ensures your dog is healthy enough for the medication.

How much does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses cost?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is $85.03 at BestVetCare. Prices may change — click through to BestVetCare for the latest.

Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses in stock at BestVetCare?

Yes, Simparica Trio For Dogs 22.1-44 Lbs (Blue) 6 Doses is currently in stock at BestVetCare.

Are there coupon codes for BestVetCare?

Yes — Love Those Deals currently tracks 4 active BestVetCare coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3913
GTIN
87219131589
MPN
Zoetis-Simparica-TRIO-2071
Last updated Apr 28, 2026