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Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses

Simparica TRIO

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is a vet-recommended chewable tablet that protects dogs against fleas, ticks, and heartworms. Priced at $166.21, it's ideal for medium-sized dogs needing year-round parasite defense with minimal effort.

$166.21

● In stock

Buy at BestVetCare →

Price and availability may change. Click to see current details on BestVetCare.

Key features

  • Triple parasite protection: fleas, ticks, heartworms
  • Fast-acting: kills fleas in 4 hours, ticks in 8
  • Monthly chewable tablet for easy dosing
  • 12-dose supply for full-year coverage
  • For dogs 22.1–44 lbs, 8 weeks and older
  • Vet-approved by Zoetis
  • Prescription-based purchase required

Pros

  • +Broad-spectrum parasite protection
  • +Fast flea and tick kill time
  • +Convenient monthly chewable form
  • +Trusted veterinary brand
  • +No messy application
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Cons

  • Requires prescription
  • Higher cost than basic flea treatments
  • Not for dogs under 22.1 lbs

About Simparica TRIO Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses

What is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is a monthly chewable tablet designed for medium-sized dogs weighing between 22.1 and 44 pounds. Formulated by Zoetis, it provides broad-spectrum protection against fleas, ticks, heartworms, roundworms, and hookworms. Each pack contains 12 pre-measured blue chews, offering a full year of parasite prevention. Administered once a month, it’s a convenient alternative to topical treatments and is approved for dogs 8 weeks and older.

Key features

  • Triple Protection — Targets fleas, ticks, and internal parasites including heartworm, roundworm, and hookworm.
  • Monthly Chewable — Easy-to-administer tablet with no mess, ideal for dogs resistant to topical solutions.
  • Fast-Acting — Starts killing fleas within 4 hours and ticks within 8 hours of administration.
  • Vet-Recommended — Manufactured by Zoetis, a trusted name in veterinary medicine.
  • Year-Round Coverage — 12-dose supply ensures continuous protection for one full year.
  • Weight-Specific Dosing — Blue dosage for dogs 22.1–44 lbs ensures accurate, safe treatment.
  • Prescription Required — Sold through authorized retailers with valid vet approval.

Who is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses for?

This product is designed for dog owners seeking reliable, once-a-month parasite control for medium-sized breeds. It’s especially beneficial for pets in high tick or heartworm regions, or those with outdoor lifestyles. Not suitable for dogs under 8 weeks or under 22.1 lbs. Ideal for owners who prefer oral medications over messy topicals.

How does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses compare?

Compared to standard flea and tick collars or monthly topicals, Simparica Trio offers broader protection by also preventing heartworm and intestinal worms. It acts faster than many oral alternatives and eliminates the residue concerns of spot-ons. While more expensive than basic flea pills, its comprehensive coverage justifies the cost for dogs needing full parasite defense. It competes directly with other prescription chewables but stands out for its rapid kill time and triple-action formula.

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Best use cases

  • Year-round heartworm prevention
  • Tick control in wooded areas
  • Flea infestation prevention
  • Monthly parasite protection for medium dogs
  • Alternative to topical treatments
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Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses right for you?

Simparica Trio is best for owners of medium-sized dogs (22.1–44 lbs) seeking comprehensive, vet-grade parasite protection. No special skills needed—just monthly administration. Requires a prescription, so consult your vet first. Alternatives include NexGard or Heartgard Plus if targeting fewer parasite types or seeking lower cost.

How it compares: Simparica Trio offers broader protection than flea-only chews or tick collars, combining heartworm, intestinal worm, and external parasite control in one fast-acting tablet, outperforming standard polypropylene rugs or fixed overhead cranes in pet health relevance.

Are There Active BestVetCare Coupons for This Product?

20% Off ⚠️ Unverified
Expires May 31
BestVetCare

Summer Must-Haves for Pets – 20% OFF Heartworm Prevention + Free Shipping*

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20% Off ⚠️ Unverified
Expires May 31
BestVetCare

Summer Must-Haves for Pets – 20% OFF Heartworm Prevention + Free Shipping*

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We earn a commission if you shop through this link.

10% Off ⚠️ Unverified
Expires May 31
BestVetCare

Set Auto-order & Get Extra 10% Discount

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30% Off ⚠️ Unverified
Expires May 31
BestVetCare

Hop into Spring Deals - 30% OFF Flea & Tick Treatments + Free Shipping!

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Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks, heartworms, roundworms, and hookworms. It’s a triple-action formula that provides comprehensive parasite control with a single monthly chewable tablet, making it ideal for year-round protection in medium-sized dogs.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a valid prescription from a licensed veterinarian. It is a prescription-only medication sold through authorized retailers like BestVetCare to ensure safe and appropriate use based on your dog’s health and weight.

How quickly does Simparica Trio work?

Simparica Trio starts killing fleas within 4 hours and ticks within 8 hours of administration. It provides rapid protection and maintains effectiveness throughout the month, helping prevent infestations and disease transmission.

Is Simparica Trio safe for all dogs?

Simparica Trio is safe for dogs 8 weeks and older weighing 22.1–44 lbs. It is not recommended for smaller dogs or those with a history of seizures. Always consult your vet before starting any new medication.

Can I buy Simparica Trio without a vet visit?

No, you cannot buy Simparica Trio without a prescription. A vet must approve its use based on your dog’s health, weight, and parasite risk. Online retailers like BestVetCare require prescription verification before shipping.

How much does Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses cost?

Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is $166.21 at BestVetCare. Prices may change — click through to BestVetCare for the latest.

Is Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses in stock at BestVetCare?

Yes, Simparica Trio For Dogs 22.1-44 Lbs (Blue) 12 Doses is currently in stock at BestVetCare.

Are there coupon codes for BestVetCare?

Yes — Love Those Deals currently tracks 4 active BestVetCare coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3913
MPN
Zoetis-Simparica-TRIO-2072
Last updated Apr 28, 2026