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Simparica TRIO Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses

Simparica TRIO

Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses

Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses is a vet-recommended chewable tablet that protects small dogs against fleas, ticks, and mites. Priced at $67.21, it offers 6 months of monthly protection for dogs weighing 2.8–5.5 lbs.

$67.21

● In stock

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Key features

  • Triple protection against fleas, ticks, and worms
  • Fast-acting: kills fleas in 4 hours
  • Monthly chewable tablet for 6 months
  • For dogs 2.8–5.5 lbs (yellow pack)
  • FDA-approved and vet-recommended
  • Waterproof and easy to administer
  • Prevents heartworm, hookworm, roundworm

Pros

  • +Broad-spectrum parasite protection
  • +Fast flea and tick kill time
  • +Convenient monthly dosing
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Cons

  • Requires prescription
  • Not for dogs under 8 weeks

About Simparica TRIO Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses

What is Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses?

Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses is a monthly chewable tablet designed for small dogs. It provides broad-spectrum protection against fleas, ticks, mange mites, and heartworms. Each pack contains six doses, offering half a year of continuous defense. Manufactured by Zoetis, Simparica Trio is FDA-approved and recommended by veterinarians for dogs in the 2.8 to 5.5-pound weight range. The yellow packaging helps identify the correct dosage for tiny breeds.

Key features

  • Triple Protection — Targets fleas, ticks, and mites while also preventing heartworm, hookworm, and roundworm.
  • Monthly Chewable — Easy-to-administer tablet that can be given with or without food.
  • Fast-Acting Formula — Starts killing fleas within 4 hours and ticks within 8 hours.
  • 6-Month Supply — Includes six pre-dosed tablets for uninterrupted protection.
  • For Small Dogs — Specifically formulated for dogs weighing 2.8 to 5.5 lbs.
  • Prescription Required — Must be used under veterinary guidance for safety and efficacy.
  • Waterproof — Remains effective after swimming or bathing.

Who is Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses for?

This product is ideal for owners of small dog breeds such as Chihuahuas, Yorkshire Terriers, and Toy Poodles. It’s best suited for pet parents seeking a reliable, vet-approved solution to prevent parasitic infestations year-round. Dogs in tick-prone areas or those frequently outdoors benefit most. It is not recommended for puppies under 8 weeks or dogs with a history of seizures.

How does Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses compare?

Compared to standard flea and tick chews, Simparica Trio offers added protection against heartworm, hookworm, and roundworm—making it a comprehensive alternative to separate dewormers. It acts faster than many topical treatments and doesn’t require post-application bathing restrictions. While pricier than single-purpose options, its broad coverage reduces the need for multiple medications, streamlining parasite control for small dogs.

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Best use cases

  • Year-round flea prevention
  • Tick protection in wooded areas
  • Heartworm prevention in high-risk zones
  • Monthly deworming for small dogs
  • Post-outdoor activity parasite defense
🛒

Is Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses right for you?

Simparica Trio is best for owners of small dogs needing comprehensive parasite protection. A prescription is required, so vet consultation is essential. Ideal for pet parents seeking a single monthly chew instead of multiple treatments. Alternatives include topical solutions or single-target oral preventives, but they lack the same breadth of coverage.

How it compares: Simparica Trio outperforms basic flea chews and topical treatments by combining flea, tick, and internal parasite control in one monthly dose, reducing medication overload for small dogs.

Are There Active BestVetCare Coupons for This Product?

10% Off ⚠️ Unverified
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Summer Must-haves for Pets €“ 20% OFF Heartworm Prevention + Free Shipping*

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Frequently Asked Questions

What does Simparica Trio protect against?

Simparica Trio protects dogs from fleas, ticks, heartworm, roundworm, hookworm, and mange mites. It’s a broad-spectrum preventive that replaces multiple separate treatments for small dogs weighing 2.8–5.5 lbs.

Does Simparica Trio require a prescription?

Yes, Simparica Trio requires a prescription from a licensed veterinarian. It is a prescription-only medication to ensure safe and appropriate use based on your dog’s health and weight.

How quickly does Simparica Trio work?

Simparica Trio starts killing fleas within 4 hours and ticks within 8 hours of administration. It provides continuous protection for a full month with each dose.

Is Simparica Trio safe for small dogs?

Yes, it’s formulated specifically for small dogs 2.8–5.5 lbs. However, it should not be used in puppies under 8 weeks or dogs with a history of seizures. Always follow vet guidance.

Can I give Simparica Trio with food?

Yes, the chewable tablet can be given with or without food. It’s designed for easy administration and remains effective regardless of meal timing.

How much does Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses cost?

Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses is $67.21 at BestVetCare. Prices may change — click through to BestVetCare for the latest.

Is Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses in stock at BestVetCare?

Yes, Simparica Trio For Dogs 2.8-5.5 Lbs (Yellow) 6 Doses is currently in stock at BestVetCare.

Are there coupon codes for BestVetCare?

Yes — Love Those Deals currently tracks 4 active BestVetCare coupons. See the coupons section on this page to copy a code before checkout.

Specifications

Brand
Simparica TRIO
Product Type
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
Category
Animals & Pet Supplies > Pet Supplies > Pet Flea & Tick Control
SKU
3913
GTIN
87219131596
MPN
Zoetis-Simparica-TRIO-2062
Last updated Apr 28, 2026