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Credelio Plus
Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews
Credelio Plus for Extra Large Dogs (22-45kg) is a beef-flavored chewable tablet priced at $104.83 for a 6-month supply that provides monthly protection against fleas, ticks, heartworm, and intestinal worms. It combines lotilaner and milbemycin oxime to kill fleas within 2 hours and treat demodex mites, roundworms, hookworms, and whipworms in dogs weighing 22 to 45 kilograms.
$104.83
✓ 30-day low
● In stock
Buy at BestVetCare →Price and availability may change. Click to see current details on BestVetCare.
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Key features
- Kills fleas within 2 hours and eliminates ticks, heartworm, and intestinal worms
- Combines lotilaner (900mg) and milbemycin oxime (33.75mg) per tablet
- Treats and prevents demodex mite infestations in dogs
- Beef-flavored chewable tablet for easy monthly administration
- Formulated specifically for dogs weighing 22 to 45 kilograms
- Provides one full month of broad-spectrum parasite protection
- Six-tablet package supplies half a year of preventative treatment
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Pros
- +Comprehensive protection against fleas, ticks, mites, and worms in one dose
- +Fast-acting flea elimination within 2 hours of administration
- +Oral chewable avoids bathing restrictions of topical treatments
- +Wide safety margin with dosing flexibility for weight ranges
- +Beef flavor improves palatability and compliance
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Cons
- −May cause vomiting, diarrhea, or decreased appetite in some dogs
- −Isoxazoline class linked to neurologic reactions including seizures
- −Requires veterinary prescription and cannot be purchased over-the-counter
- −Not suitable for dogs under 1.4 kg or puppies under 8 weeks
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About Credelio Plus Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews
What is Credelio Plus for Extra Large Dog 22-45kg (Blue) 6 Chews?
Credelio Plus for Extra Large Dog 22-45kg (Blue) 6 Chews is a prescription veterinary parasiticide manufactured by Elanco that delivers broad-spectrum protection against external and internal parasites in dogs. Each beef-flavored chewable tablet contains lotilaner (900mg) and milbemycin oxime (33.75mg), providing one month of coverage against fleas, ticks, heartworm disease, demodex mites, and gastrointestinal worms including roundworms, hookworms, and whipworms. The blue-coded formulation targets extra large dogs weighing 22 to 45 kilograms, delivering 20 to 41 mg lotilaner per kg and 0.75 to 1.53 mg milbemycin oxime per kg bodyweight.
Key features
- Dual active ingredients — lotilaner kills fleas and ticks while milbemycin oxime controls heartworm and intestinal parasites
- Rapid flea elimination — kills fleas within 2 hours of administration and targets both adult and larval stages
- Demodex mite treatment — officially recognized for treating demodex mite infestations in dogs
- Monthly dosing — administered once per month with food for continuous parasite protection
- Beef-flavored palatability — chewable tablet format designed for easy oral administration
- 6-month supply — package contains 6 tablets for half a year of parasite prevention
- Weight-specific dosing — precisely formulated for dogs 22 to 45 kg, with combination dosing available for heavier dogs
Who is Credelio Plus for Extra Large Dog 22-45kg (Blue) 6 Chews for?
This product is designed for dog owners managing extra large breeds or mixed breeds in the 22-45 kg weight range who need comprehensive parasite control from a single monthly treatment. It suits households in areas with high tick or heartworm prevalence and is appropriate for dogs 8 weeks and older. Owners should consult veterinarians before use in dogs with seizure histories, as the isoxazoline class has been associated with neurologic adverse reactions in susceptible animals.
How does Credelio Plus for Extra Large Dog 22-45kg (Blue) 6 Chews compare?
Credelio Plus offers broader parasite coverage than standard flea-and-tick treatments like Credelio (lotilaner only) by adding milbemycin oxime for heartworm and intestinal worm protection. Compared to topical alternatives such as Revolution or Advantage Multi, the oral chewable format eliminates concerns about bathing or children touching treated fur, though some dogs experience gastrointestinal side effects including vomiting and diarrhea. At $104.83 for six doses, the cost per month is approximately $17.47, positioning it competitively among combination parasite preventatives.
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Best use cases
- →Monthly parasite prevention for extra large breed dogs 22-45 kg
- →Treating demodex mange in German Shepherds, Labs, or Golden Retrievers
- →Heartworm prevention in tick-endemic regions with single tablet
- →Controlling flea infestations in multi-dog households
- →Managing intestinal worm burdens in dogs with outdoor access
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Is Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews right for you?
Dog owners with extra large breeds (22-45 kg) seeking all-in-one parasite protection should consider Credelio Plus, especially in regions with heartworm or tick-borne disease risk. It simplifies medication schedules by combining flea, tick, heartworm, and worm control in a single monthly chewable. Owners of dogs with seizure disorders or sensitivity to isoxazolines should discuss alternatives with their veterinarian. For dogs requiring only flea and tick control without heartworm prevention, standard Credelio or topical alternatives may be more cost-effective.
How it compares: Credelio Plus extends the lotilaner-only formula of standard Credelio by adding milbemycin oxime for heartworm and intestinal parasite coverage, making it comparable to combination products like Simparica Trio or NexGard Plus. The oral tablet format offers convenience over topical treatments but may cause more frequent gastrointestinal side effects than spot-on alternatives.
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Frequently Asked Questions
What is Credelio Plus for Extra Large Dog 22-45kg?
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Credelio Plus is a prescription chewable tablet manufactured by Elanco that provides monthly protection against fleas, ticks, heartworm, demodex mites, and intestinal worms in dogs weighing 22 to 45 kilograms. Each blue-coded tablet contains 900mg lotilaner and 33.75mg milbemycin oxime. The product is administered once monthly with food and kills fleas within 2 hours while preventing heartworm disease and controlling roundworms, hookworms, and whipworms.
What are the key features of Credelio Plus for Extra Large Dogs?
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Key features include dual active ingredients (lotilaner and milbemycin oxime) for broad-spectrum parasite control, rapid flea elimination within 2 hours, treatment of demodex mites, monthly oral administration, beef flavoring for palatability, and weight-specific dosing for 22-45 kg dogs. The 6-chew package provides half a year of protection. It targets both adult and larval parasites while preventing heartworm disease and controlling gastrointestinal worms in a single tablet.
Who is Credelio Plus for Extra Large Dogs for?
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Credelio Plus is designed for owners of extra large breed dogs weighing 22 to 45 kilograms who need comprehensive parasite prevention from a single monthly treatment. It suits households in tick-endemic or heartworm-prevalent regions and is appropriate for dogs 8 weeks and older. Owners should consult veterinarians before use in dogs with seizure histories, as the isoxazoline drug class has been associated with neurologic adverse reactions in susceptible animals.
Does Credelio Plus treat demodex mites in dogs?
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Yes, Credelio Plus is officially recognized for treating demodex mite infestations in dogs. The lotilaner component effectively targets demodex mites along with fleas and ticks, providing comprehensive external parasite control. This makes it suitable for managing demodex mange while simultaneously preventing heartworm and controlling intestinal parasites through the milbemycin oxime ingredient. Monthly administration maintains ongoing protection against mite reinfestation.
How does Credelio Plus compare to standard Credelio or topical treatments?
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Credelio Plus adds milbemycin oxime to standard Credelio's lotilaner formula, providing heartworm and intestinal worm protection that basic Credelio lacks. Compared to topical alternatives like Revolution, the oral chewable eliminates concerns about bathing restrictions or children touching treated fur, though some dogs experience gastrointestinal side effects. At approximately $17.47 per monthly dose, it competes with other combination products like Simparica Trio while offering broader coverage than single-action treatments.
How much does Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews cost?
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Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews is $104.83 at BestVetCare. Prices may change — click through to BestVetCare for the latest.
Is Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews in stock at BestVetCare?
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Yes, Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews is currently in stock at BestVetCare.
What condition is Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews in?
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Credelio Plus For Extra Large Dog 22-45kg (Blue) 6 Chews is sold in new condition by BestVetCare.
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Specifications
- Brand
- Credelio Plus
- Condition
- New
- Product Type
- Animals & Pet Supplies > Pet Supplies > Dog Supplies
- Category
- Animals & Pet Supplies > Pet Supplies > Dog Supplies
- Google Category
- Animals & Pet Supplies > Pet Supplies > Dog Supplies
- SKU
- 3913
- MPN
- Elanco-Credelio-Plus-2237
Last updated Apr 28, 2026